Rick, sorry to hear you had blood sugar problems on Chantix. I just started it for the third (and hopefully last) time this past Monday (5/19/08). I, too, am a diabetic, Type II, non-insulin dependant. I take Byetta and so far have had no problems with Chantix raising my blood sugars. (Wish I could say the same for Abilify, which I take for Bipolar Disorder. That pops my sugars about 40 points.) Be interesting to find out if there is a reaction between insulin and Chantix. Have you asked your diabetes doc? I wish you the best with the patch and Zyban and I do hope the increase in insulin dosage isn't permanent. I'm sure your diabetes people have already told you all this but please stick to your diabetes diet and try to walk 30 minutes every day. It really helps me. My last A1C was 6.0 and I've gone from 312 lbs to 224 lbs. Blessings. Carol