For me, I smoked for the first week, (100mg) while on it. As the days went by, I found smoking less, and less interesting. Even when I thought I wanted to smoke, and would light one, I would only smoke a few puffs and put it out cause it didn't taste the same. So, I guess yes, it did affect me in my brain chemistry. I realized if this was going to work, I still had to commit to a quit day. So on the 9th day, (300mg now), I had 3 cigs left that I threw away, including my (ass) trays, LOL, lighters, etc. and I started the JOURNEY. Bupropion lessened the withdrawal symptoms, but not completely. The first week was tough, but I wanted to LIVE more than smoke. Each week got easier and easier. I even helped my Mom who was dying from symptoms directly related to her 60ish yr smoking addiction during last xmas, and didn't even take a stupid puff. And that's huge... If ever there was a REASON to SMOKE! I am certainly not out of the woods, but I feel like I have a very strong chance to live, face, and cope with life without hiding behind a stinky smoke screen. This has been my experience thus far. Every ones journey is different. Compared to Chantix, wellbutrin was much easier for me.
I'm Grateful to be free from a 38 year addiction and life just keeps getting better and better. Everyday I'm amazed how many aspects of my life were touch by tobacco.
